I was going to say replaying but I feel like that limits the question to games like Prey or Fallout New Vegas that have endings and games like The Sims 2 or Cities Skylines where you can play indefinitely end up excluded.
I’m not really referring to games like League of Legends where you’re coming back every month. More so games where you stop playing for an extended period of time.
Binding of Isaac for sure. Been playing on and off since I was in high school and there is just so much content there and new crazy synergies to find. Across all platforms I have well over a thousand hours. Hoping I can 100% it some day!